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The treatment of high blood pressure is usually with medications which lower the blood pressure and the risk of complications is reduced. Principles of pharmacotherapy The therapy usually begins with a single agent (monotherapy), which is supplemented in the case of insufficient effect by other active ingredients. The choice of drugs depends on: the blood pressure value; concomitant diseases (Diabetes, heart failure, kidney disease); the age and gender of the patient; individual side-effect profiles. List of the most important groups of Drugs for high blood pressure ACE inhibitors (Angiotensin‑converting enzyme inhibitor) Mechanism of action: Inhibit the enzyme, and the Angiotensin I converting into the blood pressure-increasing Angiotensin II. Examples: Lisinopril, Enalapril, Ramipril. Indications: congestive heart failure, Diabetes, proteinuria, after a heart attack. Side effects: dry cough, Hyperkalemia, rarely angioedema. AT1‑receptor blockers (Sartans) Mechanism of action: Block the Angiotensin II receptors and thus prevent the blood pressure-increasing effects. Examples: Losartan, Valsartan, Candesartan. Indications: in patients who are intolerant of ACE inhibitors (for example, because of cough). Side effects: Hyperkalemia, lower risk of cough than ACE inhibitors. Calcium Antagonists (Calcium Channel Blocker) Mechanism of action: reduce the influx of calcium into the smooth muscle cells of the blood vessels, leading to vascular dilatation. Examples: amlodipine, nifedipine (Dihydropyridines), Verapamil, Diltiazem (non‑Dihydropyridines). Indications: isolated systolic hypertension in old age, Angina pectoris. Side Effects: Edema, Headache, Redness Of The Face. Diuretics (diuretics) Mechanism of action: increase the excretion of water and salt through the kidneys and reduce the volume of blood. Examples: Thiazides (hydrochlorothiazide), thiazide‑like (indapamide), loop diuretics (furosemide), Potassium-sparing (spironolactone). Indications: especially in older patients and in patients with heart failure. Side effects: electrolyte disturbances (Hypokalaemia), increased uric acid levels. Beta-blockers Mechanism of action: block the action of epinephrine on beta receptors, decrease heart rate and cardiac output. Examples: Metoprolol, Bisoprolol, Carvedilol. Indications: heart attack, heart failure, Angina pectoris. Side effects: bradycardia, fatigue, sexual dysfunction. Recommended Combinations A combination of two or more drugs is often necessary to target blood pressure (&lt;140/90 mmHg in Diabetes &lt;To achieve 130/80 mmHg). Particularly effective and well-tolerated are: ACE inhibitor + calcium antagonist; AT1‑receptor blocker + calcium antagonist; ACE inhibitor + diuretic; AT1‑receptor blocker + diuretic. Conclusion There is no best medication for all patients with hypertension. The individual therapy needs to diseases on the Basis of risk factors, monitoring and side-effect profile to be matched. The above-mentioned groups of active substances form the basis of modern hypertension therapy and have been investigated in numerous studies on efficacy and safety. Prior to the commencement of a medication for a consultation with a physician is always required. Only a specialist can determine the correct substance and dose, and the course of therapy control. Would you like me to make a part of the text in greater detail or further information to a specific group of drugs add?